COPOLYMER BEARING AMINO ACID RESIDUE ON SIDE CHAIN, THERMALLY RESPONDING POLYMER, AMINO ACID-DISCRIMINATING AGENT, AND REAGENT FOR OPTICAL RESOLUTION

摘要

PROBLEM TO BE SOLVED: To obtain the subject copolymer that has further higher transition point and can manifest the functions of recognition of amino acids and optical resolution by copolymerizing a monomer bearing an amino acid residue on its side chain and an N-isopropylacrylamide. SOLUTION: This copolymer is represented by formula I ((m), (n) are each the proportion in weight% of individual components in the copolymer) and is obtained by copolymerizing a compound of formula II (Z is a protecting group for H atom in an amino group; Y is a protecting group for hydroxyl in a carboxyl group, for example, benzyl and the like; protecting group Z is benzyloxycarbonyl, t-butoxy-carbonyl) with N-isopropylacrylamide followed by deprotection of the protecting groups Z and Y. This copolymer is dissolved in water at a lower temperature than the transition point, but causes a phase separation above the transition point and the aqueous solution becomes cloudy, thus it can be expectedly used as a thermally responding polymer. In addition, the copolymer can also be used as a reagent for discrimination of kinds of amino acids and for resolution of amino acids.