Method for controlling bleeding and microbial infections by administering thrombin, casein kinase II, and sphingosine

摘要

PCT No. PCT/KR95/00189 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Dec. 30, 1995 PCT Pub. No. WO96/23523 PCT Pub. Date Aug. 8, 1996The present invention relates to a hemostatic composition comprising at least 0.1 NIH U/ml of thrombin, about 0.01 mU/ml of casein kinase II, and from 10 ng/ml to 100 ng/ml of sphingosine or a sphingosine derivative. The composition is effective in treating patients suffering from hemophilia, ulcers, or microbial infections. In addition, the composition is effective in reducing clotting time during the surgical procedure of suturing blood vessels.