发明名称 Aryl thiophene derivatives as pde iv inhibitors
摘要 The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula (I).
申请公布号 AU9334798(A) 申请公布日期 1999.04.27
申请号 AU19980093347 申请日期 1998.10.01
申请人 MERCK FROSST CANADA & CO. 发明人 YONGXIN HAN;DWIGHT MACDONALD;ANDRE GIROUX;ROBERT N. YOUNG;HELENE PERRIER;CAROLE LEPINE
分类号 C07D333/18;A61K31/381;A61K31/443;A61K31/4433;A61K31/4436;A61K31/497;A61K31/506;A61P11/06;A61P43/00;C07D333/16;C07D333/24;C07D333/34;C07D405/12;C07D409/04;C07D409/12;C07D409/14;C07D417/14 主分类号 C07D333/18
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