发明名称 |
LIGAND BINDING SITE OF RAGE AND USES THEREOF |
摘要 |
The present method provides for an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of a receptor for advanced glycation end product (RAGE). The present invention also provides for an isolated peptide having an amino acid sequence A-Q-N-I-T-A-R-I-G-E-P-L-V-L-K-C-K-G-A-P-K-K-P-P-Q-R-L-E-W-K (Seq. ID No. 1). The present invention provides for a pharmaceutical composition comprising a therapeutically effect amount of an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of RAGE. The present invention also provides for a method for inhibiting interaction of an amyloid- beta peptide with a receptor for advanced glycation end product which is on the surface of a cell, which comprises contacting the cell with the peptide or a functionally equivalent agent, wherein the peptide or agent is capable of inhibiting interaction of the amyloid- beta peptide with the receptor for advanced glycation end product, and the peptide or agent is present in an amount effective to inhibit interaction of the amyloid- beta peptide with the receptor for advanced glycation end product.
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申请公布号 |
WO9918987(A1) |
申请公布日期 |
1999.04.22 |
申请号 |
WO1998US21346 |
申请日期 |
1998.10.09 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
STERN, DAVID;YAN, SHI, DU;SCHMIDT, ANN, MARIE;LAMSTER, IRA |
分类号 |
C12P21/08;A61K9/06;A61K9/08;A61K9/12;A61K9/14;A61K38/00;A61K39/395;A61K47/48;A61P1/02;A61P3/10;A61P9/10;A61P15/10;A61P17/02;A61P21/02;A61P25/28;A61P29/00;A61P35/00;A61P37/06;A61P43/00;C07K7/04;C07K14/705;C07K16/00;(IPC1-7):A61K38/00;C07K5/00 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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