发明名称 |
SCREENING FOR NOVEL COMPOUNDS WHICH REGULATE BIOLOGICAL INTERACTIONS |
摘要 |
Disclosed is a process for identifying compounds having a specified activity of interest, which process comprises (i) introducing interacting molecules into a host cell under conditions to generate or repress a detectable signal; and (ii) introducing a third compound or gene or genes encoding a third compound into the host cell from (i); and (iii) screening said host cell utilizing a method for detecting the inhibition or enhancement of interaction of proteins or other molecules in an in vivo or in vitro system. Another aspect of the present invention provides a process for identifying compounds of interest, which process comprises (i) generating one or more expression libraries derived from nucleic acid directly isolated from the environment; and (ii) screening said libraries utilizing a method for detecting the inhibition or enhancement of interaction of proteins or other molecules in an in vivo or in vitro system.
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申请公布号 |
WO9919518(A1) |
申请公布日期 |
1999.04.22 |
申请号 |
WO1998US21895 |
申请日期 |
1998.10.15 |
申请人 |
DIVERSA, INC.;SHORT, JAY, M. |
发明人 |
SHORT, JAY, M. |
分类号 |
G01N33/50;C12N15/09;C12N15/10;C12P7/26;C12Q1/02;C12Q1/26;C12Q1/34;C12Q1/48;C12Q1/68;C12R1/01;G01N33/15;G01N33/53;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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