| 发明名称 |
ISO-CBI AND ISO-CI ANALOGS OF CC-1065 AND THE DUOCARMYCINS |
| 摘要 |
A series of bioactive analogs of (+)-CC-1065 (1) and the duocarmycins 2 and 3 are synthesized. The bioactive analogs include either iso-CI or iso-CBI (6 and 7) as a DNA alkylation subunit. Conjugated to the DNA alkylating subunits are a variety of DNA binding subunits. The bioactive analogs maintain their DNA selectivity and display enhance reactivity.
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| 申请公布号 |
CA2306420(A1) |
申请公布日期 |
1999.04.22 |
| 申请号 |
CA19982306420 |
申请日期 |
1998.10.14 |
| 申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
BOGER, DALE L. |
| 分类号 |
A61K31/403;A61K31/404;A61P35/00;A61P43/00;C07D209/12;C07D209/42;C07D209/60;C07D209/70;C07D209/94;C07D487/04;(IPC1-7):C07D209/04;C07D403/06;C07D403/14;C07D209/56;C07D209/80;C07D209/90 |
主分类号 |
A61K31/403 |
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