发明名称 |
Novel hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof |
摘要 |
The present invention relates to novel hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the general formulae I, II, III and IV: <CHEM> wherein R<1> = R<2> = 4-hydroxycoumarin; R<1> = R<2> = 4,7-dihydroxycoumarin; R<1> = R<2> = 4,5,7-trihydroxycoumarin; R<1> = 4-hydroxycoumarin, R<2> = -CH(OH)CH3. An object of the invention are also processes for the preparation of hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids, and the antiviral action thereof. Novel hydroxy and polyhydroxy derivatives of coumarin according to the present invention exhibit antiviral action against HIV-1 virus. |
申请公布号 |
AU8788698(A) |
申请公布日期 |
1999.04.22 |
申请号 |
AU19980087886 |
申请日期 |
1998.10.01 |
申请人 |
PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRI |
发明人 |
MLADEN TRKOVNIK;ZRINKA IVEZIC |
分类号 |
C07D311/42;A61K31/35;A61K31/352;A61K31/353;A61K31/37;A61P31/12;A61P31/18;A61P37/04;C07D311/44;C07D311/46;C07D311/48;C07D311/54;C07D311/56;C07D407/06;C07D407/10;C07D407/14 |
主分类号 |
C07D311/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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