COMPLEX OF BIOTINYLATED VIRAL VECTOR AND LIGAND FOR TARGETED GENE DELIVERY
摘要
The present invention provides methods and a composition for targeted delivery of a nucleic acid to a cell comprising a biotinylated recombinant encapsidated virus, particularly adenovirus, wherein the recombinant adenovirus comprises the nucleic acid, and wherein the biotinylated recombinant virus is linked via streptavidin to a biotinylated targeting moiety.
申请公布号
WO9919500(A1)
申请公布日期
1999.04.22
申请号
WO1998US21364
申请日期
1998.10.09
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALT H AND HUMAN SERVICES;SPENCE, SALLY, E.;KELLER, JONATHAN, R.;SMITH, JEFFREY, S.
发明人
SPENCE, SALLY, E.;KELLER, JONATHAN, R.;SMITH, JEFFREY, S.
