TRANSGENIC ANIMAL MODELS FOR CARDIAC HYPERTROPHY AND USES THEREOF
摘要
Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the invention. Further provided are transgenic animals generated using the transgene constructs. Further provided are enzyme-based, cell-based, and whole-animal-based assays for detecting substances having therapeutic activity toward cardiac hypertrophy. Further provided are compositions comprising substances which modulate levels of active product of a hypertrophy-sensitive gene. Further provided are methods of treating cardiac hypertrophy.
申请公布号
WO9919473(A1)
申请公布日期
1999.04.22
申请号
WO1998US21988
申请日期
1998.10.16
申请人
MANTEX BIOTECH INC.;GRANT, STEPHEN, R.;OLSON, ERIC, N.;MOLKENTIN, JEFFREY, D.
发明人
GRANT, STEPHEN, R.;OLSON, ERIC, N.;MOLKENTIN, JEFFREY, D.