发明名称 |
METHOD FOR INHIBITING THE BINDING OF LOW DENSITY LIPOPROTEIN TO BLOOD VESSEL MATRIX |
摘要 |
This invention also provides a method of treating atherosclerosis in a subject, comprising administering to the subject an effective amount of a substance capable of binding the amino-terminal region of apolipoprotein B, thereby treating the atherosclerosis. This invention also provides a method for inhibiting the binding of low density lipoprotein to blood vessel matrix in a subject, comprising administering to the subject an effective amount of a substance capable of competing with the amino-terminal region of apolipoprotein B for binding to blood vessel matrix, thereby inhibiting the binding of low density lipoprotein to blood vessel matrix. This invention also provides a method for identifying a compound capable of ameliorating atherosclerosis. Additionally, this invention provides a kit for inhibiting the binding of low density lipoprotein to blood vessel matrix, wherein the kit comprises a substance capable of binding to the amino-terminal region of apolipoprotein B.
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申请公布号 |
WO9918986(A1) |
申请公布日期 |
1999.04.22 |
申请号 |
WO1998US21345 |
申请日期 |
1998.10.09 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;GOLDBERG, IRA, J.;PILLARISETTI, SIVARAM |
发明人 |
GOLDBERG, IRA, J.;PILLARISETTI, SIVARAM |
分类号 |
A61K38/00;A61K38/17;C07K14/775;C07K16/18;(IPC1-7):A61K38/00;A61K39/395;C12N15/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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