ENHANCED IMMUNOGENIC CELL POPULATIONS PREPARED USING H2 RECEPTOR ANTAGONISTS

摘要

This invention provides a method to enhance alloactivation in a mixed lymphocyte culture. Alloactivated cells are effective in treating tumors when implanted into a tumor site or coinjected with tumor cells as a vaccine. By enhancing allocativation, more cell combinations achieve a threshold of activation adequate for use in therapy, and the level of cytokine secretion in proliferative phase cultures is generally increased.