发明名称 |
IMMUNO-REACTIVE PEPTIDE CTL EPITOPES OF HUMAN CYTOMEGALOVIRUS |
摘要 |
<p>The invention provides a plurality of peptides (and immunologically functional variants thereof) which are immunogenic epitopes recognized by CD8<+> class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent cytomegalovirus (HCMV) infection. The peptides are capable of activating CTLs and CTLp's in the absence of active viral replication, and thus are useful for eliciting a cellular immune response against HCMV by normal and immunodeficient subjects. Polypeptide and lipopeptide vaccines, with and without adjuvants, are also disclosed.</p> |
申请公布号 |
WO9919349(A1) |
申请公布日期 |
1999.04.22 |
申请号 |
WO1998US09652 |
申请日期 |
1998.05.11 |
申请人 |
CITY OF HOPE |
发明人 |
DIAMOND, DON, JEFFREY;YORK, JOANNE |
分类号 |
A61K38/00;A61K39/00;A61K39/245;A61K48/00;A61P31/12;A61P31/22;A61P37/04;C07K14/045;C12N5/06;C12N15/09;G01N33/569;(IPC1-7):C07K14/045;C12N15/86 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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