| 摘要 |
<p>Novel modified oligodeoxyribonucleotides having an excellent activity against human immunodeficiency virus (HIV-1). They are compounds represented by general formula (1) or pharmacologically acceptable salts thereof, wherein Q is a group represented by R1R2R3Z (wherein R1, R2, and R3 each represents H, C1-4 alkyl, optionally substituted aryl, or optionally substituted anthraquinonyl and Z represents C or Si, or R2, R3 and Z in combination represent fluorenyl or xanthenyl); R4 is H, optionally substituted C1-4 alkyl, optionally substituted aryl, or optionally substituted aralkyl; Y1, Y3, and Y4 each is O, S, or NH; Y2 is O, S, NH, C1-4 alkylene, or phenylene; Z is C or Si; X is C1-10 alkylene optionally substituted by OH; m and n each is an integer of 0 to 10; and B is an oligodeoxyribonucleotide having a sequence represented by TGGGGT, TGGGGTT, TGGGGGT, TGGGCG, TGGGTG, TGGGG, TGGGGG, or TGGGAG.</p> |
