发明名称 |
CANCER IMMUNOTHERAPY USING ALLOSTIMULATED CELLS IN A MULTIPLE SEQUENTIAL IMPLANTATION STRATEGY |
摘要 |
This invention provides medicaments and methods for managing cancer using donor cells that are alloactivated in culture. Alloactivated cells are implanted into the bed of a solid tumor and initiate a response by the host against the tumor. Subsequently, alloactivated cells are implanted into the bed of a solid tumor a second time. The two implants work synergistically to confer remarkable benefit to the treated subject, both in terms of managemen t of the cancer and the development of an anti-cancer immune response. The beneficial effects may include regression of the tumor and extended survival . Removal of any residual tumor after the second implant facilitates ongoing resistance to tumor regrowth or metastasis.
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申请公布号 |
CA2346735(A1) |
申请公布日期 |
1999.04.22 |
申请号 |
CA19982346735 |
申请日期 |
1998.09.29 |
申请人 |
MEYER PHARMACEUTICALS, LLC |
发明人 |
HISERODT, JOHN C. |
分类号 |
A61K38/00;A61K39/00;C12N5/0783;(IPC1-7):A61K35/14;C12N5/06;C12N5/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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