发明名称 |
BIOSENSOR ELECTRODE MEDIATORS FOR REGENERATION OF COFACTORS |
摘要 |
The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
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申请公布号 |
CA2305800(A1) |
申请公布日期 |
1999.04.22 |
申请号 |
CA19982305800 |
申请日期 |
1998.10.16 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
SANGHERA, GURDIAL S.;FORROW, NIGEL J.;WATKIN, JARED L.;WALTERS, STEPHEN |
分类号 |
G01N27/327;C12Q1/00;(IPC1-7):C12Q1/32;G01N27/30 |
主分类号 |
G01N27/327 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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