| 发明名称 |
METHOD FOR DETECTION OF METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENCY IN MAMMALIAN CELLS |
| 摘要 |
<p>Catalytically active and inactive MTAse (methyladenosine phosphatase) are detected in mammalian cells by (1) treating cells suspected of being MTAse deficient with an oligonucleotide probe that hybridises specifically to an MTAse encoding nucleic acid and (2) detecting whether such nucleic acid is present. Also new are (1) isolated polynucleotides (I) encoding MTAse, (2) recombinant expression vectors contg. (I) or its fragments, (3) MTAse (or its fragments) expressed from these vectors or prepd. synthetically, (4) antibodies (Ab) raised against MTAse or its fragment.</p> |
| 申请公布号 |
EP0733123(A4) |
申请公布日期 |
1999.04.21 |
| 申请号 |
EP19950907260 |
申请日期 |
1994.12.22 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
NOBORI, TSUTOMU;CARSON, DENNIS, A.;TAKABAYASHI, KENJI |
| 分类号 |
G01N33/566;C07H21/04;C07K7/06;C07K7/08;C07K16/40;C12N1/21;C12N5/06;C12N9/10;C12N9/12;C12N15/00;C12N15/02;C12N15/09;C12P19/34;C12P21/08;C12Q1/00;C12Q1/25;C12Q1/68;C12R1/19;C12R1/91;G01N33/50;G01N33/573;(IPC1-7):C12Q1/00;C07K1/00;C07H17/00;C07K17/00;A61K38/00;A61K35/14 |
主分类号 |
G01N33/566 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
