摘要 |
The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective ingredient. <CHEM> ÄIn the formula, X and Y each is any group selected from a group consisting of CH2, CHW<1> (where W<1> is halogen atom, hydroxyl group or lower alkoxy group) and C=O when the bond of X and Y is a single bond while, when it is a double bond, X and Y each is any group selected from a group consisting of CH and COW<2> (where W<2> is lower alkyl group or lower alkylcarbonyl group); Z is O, S, S=O or SO2; and R<1> SIMILAR R<8> each is selected from a group consisting of hydrogen atom, VR<9> (where V is O, S, S=O or SO2; and R<9> is hydrogen atom, lower alkyl group, hydroxy lower alkyl group, lower acyl group, trihalomethyl group or carboxyl lower alkyl group), carboxyl lower alkyl group, hydroxy lower alkyl group, hydroxy lower alkenyl group, hydroxy lower alkynyl group, halogen atom, lower alkyl group, lower alkyl ketone, trihalomethyl group, trimethylsilylethynyl, nitro group, amino group, N-carbonyl lower alkyl group, lower alkylphenyl group and phenyl groupÜ. |
申请人 |
NIPPON SUISAN KAISHA, LTD. |
发明人 |
YAMASHITA, SHINYA;TAKEO, JIRO;JINNO, SHUJI;KOGURE, YASUYO;ONUKI, HIROYUKI;OKITA, TAKAAKI;HATA, JUNICHIRO;FUKUDA, YASUHIRO;OHTSUKA, NAOMI |