Process for producing nucleoside derivatives

摘要

There is disclosed a process for producing a nucleoside derivative of the formula ÄIÜ: characterized by contacting 2',3',5'-O-triacylribonucleoside derivative of the formula ÄIIÜ: with an ester hydrolase: (i) capable of regio-selectively deacylating the acyl group at 5'-O-position in the formula ÄIIÜ above, and (ii) having an amino acid sequence encoded by a gene which hybridizes to a nucleotide sequence encoding an amino acid sequence of SEQ ID NO: 1