IMMUNOCONJUGATE, A METHOD OF AN IMMUNOCONJUGATE PREPARING AND A PHARMACEUTICAL COMPOSITION

摘要

FIELD: biochemistry, medicine, oncology, pharmacy. SUBSTANCE: immunoconjugate is a monoclonal antibody or its fragment connected with biologically active ligand. Antibody or its fragment is directed against tumor cell carrying an antigenic epitope of epidermal growth factor receptor. Cytokine is used as a biologically active ligand. For preparing an immunoconjugate DNA sequence encoding antibody or its fragment is fused with DNA sequence encoding a biologically active ligand. Obtained structure is introduced in an expression vector which is cultured in host cells. Invention related to new fused protein can be used for treatment of patients with tumor diseases being with any tumors species. EFFECT: improved method of preparing, enhanced effectiveness of an immunoconjugate obtained. 13 cl, 10 dwg, 2 tbl