| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to a pharmaceutical composition containing a compound of the general formula or its salt: <EMI ID=0.49 HE=36 WI=36 TI=CHI> where R means thienyl, pyridyl, aryl; R means hydrogen atom, alkyl, phenyl; R and R mean independently hydrogen atom or alkyl, or R and R taken together with adjacent N-atom mean 6-membered heterocycle; A means C<SB>2</SB>-C<SB>6</SB>-alkylene; W means direct bond, O, S or (CH<SB>2</SB>)<SB>n</SB>; n = 1 or 2; X, Y and Z can be similar or distinct and each means CH (the latter can be a substituted alkyl), or N-atom. However, X, Y and Z can not mean CH simultaneously. Synthesized compounds exhibit the strong inhibiting activity with respect to neurons death and can be used as a therapeutic drug in cerebrovascular sicknesses. EFFECT: improved method of synthesis, enhanced effectiveness of drug. 17 cl, 1 tbl, 40 ex
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