发明名称 |
Accumulations of amino acids and peptides into liposomes |
摘要 |
The present invention relates to liposomal compositions having a concentration gradient which load amino acids and peptides exhibiting weak acid or base characteristics into liposomes. Specifically loaded into liposomes by the methods of the present invention are C-terminal substituted amino acids or peptides. The liposomes are preferably large unilamellar vesicles. The concentration gradient is formed by encapsulating a first medium in the liposomes, said medium having a first concentration of the one or more charged species, and suspending the liposomes in a second medium having a second concentration of the one or more charged species, such as for example a pH gradient. Also disclosed are pharmaceutical preparations comprising such C-terminal substituted amino acids or peptides which have been loaded into the liposomes by the method of the invention. |
申请公布号 |
HK1007497(A1) |
申请公布日期 |
1999.04.16 |
申请号 |
HK19980106742 |
申请日期 |
1998.06.25 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
AJOY CHAKRABARTI;IAN CLARK-LEWIS;PIETER R. CULLIS |
分类号 |
A61K9/127;A61K31/223;A61K38/00;A61K38/10;A61K38/22;A61K38/25;(IPC1-7):A61K |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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