发明名称 |
BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-CO-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES |
摘要 |
A water soluble biodegradable ABA- or BAB- type triblock polymer is disclosed that is made up of a major amount of a hydrophobic polymer made up of a poly(lactide-co-glycolide) copolymer or poly(lactide) polymer as the A-blocks and a minor amount of hydrophilic polyethylene glycol polymer B-block, having an overall weight average molecular weight of between about 2000 and 4990, and that possesses reverse thermal gelation properties. Effective concentrations of the triblock polymer and a drug may be uniformly contained in an aqueous phase to form a drug delivery composition. The release rate of the drug may be adjusted by changing various parameters such as hydrophobic/hydrophilic component content, polymer concentration, molecular weight and polydispersity of the triblock polymer. Because the triblock polymer is amphiphilic, it functions to increase the solubility and/or stability of drugs in the composition, as demonstrated by a phase diagram illustrating the gelation behaviour of aqueous solutions of a PLGA-PEG-PLGA triblock copolymer studied at different concentrations and temperatures.
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申请公布号 |
CA2305621(A1) |
申请公布日期 |
1999.04.15 |
申请号 |
CA19982305621 |
申请日期 |
1998.10.02 |
申请人 |
MACROMED, INC. |
发明人 |
JEONG, BYEONGMOON;RATHI, RAMESH;ZENTNER, GAYLEN M. |
分类号 |
A61K9/00;A61K9/107;A61K31/17;A61K31/282;A61K31/337;A61K31/437;A61K31/519;A61K31/704;A61K31/7042;A61K38/00;A61K38/04;A61K38/11;A61K38/17;A61K38/21;A61K38/22;A61K38/24;A61K38/26;A61K38/27;A61K38/28;A61K38/43;A61K39/00;A61K39/395;A61K45/00;A61K47/30;A61K47/32;A61K47/34;A61P35/00;C08G63/08;C08G63/664;C08G65/329;C08G81/00;C08L67/00;C08L71/02;(IPC1-7):C08G65/32;C08G63/91 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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