Increasing microbial production of specific amino acids by increasing activity or expression of pyruvate carboxylase
摘要
Microbial production of amino acids (A) of the asparate and/or glutamate families comprises increasing pyruvate carboxylase (PC) activity by genetic alteration of the enzyme and/or increasing expression of the PC gene in appropriate microorganisms. Independent claims are also included for the following: (1) a PC gene (I) encoding a 1104 amino acid enzyme (II) and/or its allelic variants; (2) gene construct containing (I); (3) vector containing (I) or the construct; and (4) transformed cells containing, in a replicable form, (I) or the construct.
申请公布号
DE19831609(A1)
申请公布日期
1999.04.15
申请号
DE1998131609
申请日期
1998.07.14
申请人
FORSCHUNGSZENTRUM JUELICH GMBH, 52428 JUELICH, DE
发明人
PETERS-WENDISCH, PETRA, DR., 51469 BERGISCH GLADBACH, DE;EIKMANNS, BERND, PROF. DR., 89081 ULM, DE;SAHM, HERMANN, PROF. DR., 52428 JUELICH, DE