| 摘要 |
<p>A process of preparing ring E-modified analogues of (-)-podophyllotoxin as potential new chemotherapeutic agents. The process generates corresponding analogues of (-)-podophyllotoxin, itself, aand allows new molecular interactions in the southern hemisphere (ring E) of the molecule. A method of preparing enantiomericallyenriched compounds of formulas (I) and (II), wherein R is (1); wherein X, X', Y, Y' and Z are ring E substituents and R1 is one of a)-e) below: a)-OH, b) an ether or glycoside, c) a substituted or unsubsituted amine or aniline, d) a C¿2?-C8 alkenyl, preferably -CH2CH=CH2, e) a C1-C8 alcohol, preferably -CH2CH2CH2OH. The process produces enantiomerically enriched compounds which do not occur naturally and are not readily available from (-)-podophyllotoxin.</p> |
