发明名称 |
AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS |
摘要 |
A compound of formula (I) wherein R<1> is hydrogen, methyl, ethyl, methoxy or methylthio; R<2> and R<3> each independently is hydrogen or lower alkyl; R<4> is hydrogen, lower alkyl, methoxy, ethoxy or benzyloxy; R<5> is lower alkyl, lower cycloalkyl, (CH2)mC(O)OR<6> wherein m is the integer 1 or 2 and R<6> is lower alkyl, phenyl optionally substituted; optionally Het or Het(lower alkyl); or R<4> and R<5> together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with C(O)O-benzyl or with phenyl optionally substituted with C(O)OR7 wherein R7 is lower alkyl or (lower alkyl)phenyl; and Z is lower alkyl or optionally substituted phenyl or Het; with the proviso that when Z is (CH2)p-(Het), then R<2> and R<3> each is hydrogen; or a therapeutically acceptable acid addition salt thereof.
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申请公布号 |
WO9918072(A1) |
申请公布日期 |
1999.04.15 |
申请号 |
WO1998CA00953 |
申请日期 |
1998.10.06 |
申请人 |
BOEHRINGER INGELHEIM (CANADA) LTD.;YOAKIM, CHRISTIANE;DEZIEL, ROBERT;OGILVIE, WILLIAM, W.;O'MEARA, JEFFREY |
发明人 |
YOAKIM, CHRISTIANE;DEZIEL, ROBERT;OGILVIE, WILLIAM, W.;O'MEARA, JEFFREY |
分类号 |
A61K31/397;A61K31/41;A61K31/4184;A61K31/422;A61K31/427;A61K31/428;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4725;A61K31/5377;A61P31/22;C07D205/08;C07D401/06;C07D401/12;C07D403/06;C07D405/06;C07D405/12;C07D409/06;C07D413/06;C07D417/06;(IPC1-7):C07D205/08;A61K31/395 |
主分类号 |
A61K31/397 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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