COMPOUNDS AND METHODS

摘要

This invention relates to substituted 3-(4-piperidinyl)indoles which are modulators, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders (for example, atopic dermatitis and allergies), rheumatoid arthritis, sarcoidosis and other fibrotic diseases, atherosclerosis, psoriasis, autoimmune diseases such as multiple sclerosis, and inflammatory bowel disease, all in mammals, by the use of substituted 3-(4-piperidinyl)indoles which are CCR5 receptor modulators. Furthermore, since CD8+ T cells have been implicated in Chronic Obstructive Pulmonary Disease ("COPD"), CCR5 may play a role in their recruitment and therefore antagonists to CCR5 could provide potential therapeutic in the treatment of COPD. Also, since CCR5 is a co-receptor for the entry of Human Immunodeficiency Virus ("HIV") into cells, receptor modulators may be useful in the treatment of HIV infection.