TRANSGENIC ANIMALS WITH KNOCKED-IN VEC RECEPTOR GENES AND USES THEREOF

摘要

The present invention provides a non-human transgenic animal whose cells express a foreign DNA sequence that encodes a functional vascular endothelial cell receptor domain, but do not express a substantially homologous native DNA sequence. This invention also provides methods of using these transgenic animals for identifying therapeutic and other reagents that affect angiogenesis. Additionally provided are methods of using transgenic animals whose cells contain any donor genes as models for testing various reagents.