TAXOID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME

摘要

To develop galactose or mannose derivatives such as docetaxel improved both in solubility and physiological activity to thereby give efficacious remedies for cancer while inposing lessened burden to patients. Taxoid derivatives consisting of paclitaxel, docetaxel or 10-deacetylbaccatin III bonded via a spacer to galactose or mannose; and a process for producing taxoid derivatives characterized by reacting paclitaxel, docetaxel or 10-deacetylbaccatin III with hydroxygalactoside tetrabenzylacetate or hydroxymannoside tetrabenzylacetate and debenzylating the reaction product optionally followed by detriethylsilylation.