TREATING OCCLUSIVE PERIPHERAL VASCULAR DISEASE AND CORONARY DISEASE WITH COMBINATIONS OF HEPARIN AND AN ADENOSIDE A2 AGONIST, OR WITH ADENOSINE

摘要

Compositions and methods for treatment of occlusive peripheral vascular disease and coronary disease are disclosed. The compositions and methods allow treatment of diseases associated with occlusion of coronary vessels, for example, by promoting growth of new blood vessels, i.e., angiogenesis and/or by recruitment of collaterals. The methods involve the co-administration of an adenosine A2 receptor agonist, e.g. adenosine, and heparin and/or a heparinlike substance over a period of several days. In particular, this invention is applicable to improving collateral coronary circulation in patients suffering from myocardial infarction.