发明名称 |
AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS |
摘要 |
A compound of formula (I) wherein R1 is hydrogen, methyl, ethyl, methoxy or methylthio; R2 and R3 each independently is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl, methoxy, ethoxy or benzyloxy; R5 is lower alkyl, lower cycloalkyl, (CH2)mC(O)OR6 wherein m is the integer 1 or 2 and R6 is lower alkyl, phenyl optionally substituted; optionally Het or Het(lower alkyl); or R4 and R5 together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with C(O)O-benzyl or with phenyl optionally substituted with C(O)OR7 wherein R7 is lower alkyl or (lower alkyl)phenyl; and Z is lower alkyl or optionally substituted phenyl or Het; with the proviso that when Z is (CH2)p-(Het), then R2 and R3 each is hydrogen; or a therapeutically acceptable acid addition salt thereof.
|
申请公布号 |
CA2301543(A1) |
申请公布日期 |
1999.04.15 |
申请号 |
CA19982301543 |
申请日期 |
1998.10.06 |
申请人 |
BOEHRINGER INGELHEIM (CANADA) LTD. |
发明人 |
DEZIEL, ROBERT;OGILVIE, WILLIAM W.;YOAKIM, CHRISTIANE;O'MEARA, JEFFREY |
分类号 |
A61K31/397;A61K31/41;A61K31/4184;A61K31/422;A61K31/427;A61K31/428;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4725;A61K31/5377;A61P31/22;C07D205/08;C07D401/06;C07D401/12;C07D403/06;C07D405/06;C07D405/12;C07D409/06;C07D413/06;C07D417/06;(IPC1-7):C07D205/08;A61K31/395 |
主分类号 |
A61K31/397 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|