| 摘要 |
The instant invention presents a rapid simple method for preparing solid phases, preferably beads, with antigens or other substituents presented on the surface in such a manner that the antigens/substituents retain their original functionality and conformation, as well as much of their native structure, to permit their use in a wide array of applications. Specifically, the substituent is attached to the surface of the solid phase by using a bifunctional derivative of polyethylene glycol. The polyethylene glycol (PEG), it has been found, acts not only to facilitate the attachment of the substituent to the solid surface, but also acts as a buffer to prevent or reduce any interaction of the solid surface with the attached substituent or, indeed, with any other biological compounds to which it may become exposed during the use of the solid surface conjugates. |
