The invention relates to a method for determining active agents which influence the covalent bonding of polypeptides on the surface of gram-positive bacteria according to the following steps: a) preparation of a gram-positive bacteria sample having or forming at least one enzymatic reporter substance which is or can be covalently bonded with the surface of the gram-positive bacteria. The sample having at least one reporter substance which is not covalently bonded on the surface of the gram-positive bacteria comprises an additional enzymatic activity as a covalent bonding on the surface of gram-positive bacteria; b) bringing the sample into contact with a possible active agent and; c) determining the enzymatic activity of the reporter substance of the sample gram-positive bacteria.
申请公布号
WO9916894(A1)
申请公布日期
1999.04.08
申请号
WO1998EP06137
申请日期
1998.09.26
申请人
EVOTEC BIOSYSTEMS AG;STRAUSS, ANDREAS;THUMM, GUENTHER;POHLNER, JOHANNES;GOETZ, FRIEDRICH
发明人
STRAUSS, ANDREAS;THUMM, GUENTHER;POHLNER, JOHANNES;GOETZ, FRIEDRICH