SPECIFIC STEADY-STATE R-TYPE Ca<2+> CHANNEL BLOCKERS AND USE THEREOF

摘要

The present invention relates to Ca<2+> channel blockers and more particularly to the R-type Ca<2+> channel blockers. More specifically, the invention relates to Ca<2+> channel blockers activity of Mandevilla velutina and Mandevilla illustris. The present invention further concerns saponin-like compounds isolated from Mandevilla species. The present invention also relates to the treatment of several pathologies that involve the nifedipine-insensitive but isradipine sensitive steady-state R-type Ca<2+> channel and the use of steady-state R-type Ca<2+> channel blockers in the treatment of these pathologies.