METHODS TO MODULATE BLOOD PRESSURE AND DIAGNOSE BARTTER'S SYNDROME TYPE III

摘要

Methods of identifying agonists or antagonists of the CLCNKB gene and the protein it encodes are disclosed. The invention also relates to the use of such agents to treat hypertension, conditions involving abnormal fluid volume and congestive heart failure and conditions related thereto. Also provided are compositions and methods for determining whether a patient is affected by or carries a mutation in the CLCNKB gene or the proteins they encode. The invention also relates to specific mutated nucleic acid sequences of the CLCNKB gene that give rise to Bartter's Syndrome Type III.