| 摘要 |
<p>Remedies for diseases caused by insulin resistance which contain as the active ingredient a substance having an activity of inhibiting the binding of the whole insulin receptor substrate-1 (IRS) or insulin receptor substrate-2 (IRS-2) or a part of the same to the whole 14-3-3 protein or a part of the same; and a method of screening remedies for diseases caused by insulin resistance which comprises assaying the above-mentioned binding inhibitory activity. Use of this screening method makes it possible to obtain remedies for various diseases induced by insulin resistance, such as diabetes, diabetic microangiopathies (diabetic nephropathy, diabetic neuropathy and diabetic retinopathy), impaired glucose tolerance, hyperinsulinemia, hyperlipemia, arteriosclerosis, hypertension, obesity, ischemic heart diseases, ischemic brain disorders, peripheral embolism, etc.</p> |
