PROCESS FOR PRODUCING SUBSTITUTED ALKYLAMINES OR SALTS THEREOF
摘要
A process for producing substituted alkylamines of general formula (3) or salts thereof, characterized by reacting a metal salt of a 2-aminothiophenol derivative of general formula (1) with an amino acid N-carboxy anhydride of general formula (2) and cyclizing the obtained product under acidic conditions. By this process, substituted alkylamines typified by 1-(2-benzothiazolyl)alkylamines and salts thereof can be produced in high yields from 2-aminothiophenol derivatives on an industrial scale while keeping excellent handling properties. Even when the intended substituted alkylamine is an optically active compound, the intended product can be produced without reducing the optical purity of the optically active starting material.
申请公布号
WO9916759(A1)
申请公布日期
1999.04.08
申请号
WO1998JP04284
申请日期
1998.09.24
申请人
IHARA CHEMICAL INDUSTRY CO., LTD.;UMEZU, KAZUTO;TANIGUCHI, SHUJI;OGAWA, MAHITO;HIYOSHI, HIDETAKA