EPITOPES AND ACTIVE SITES OF PARAMYXOVIRIDAE PROTEINS AND USES THEREOF

摘要

The invention relates to the field of paramyxoviridae, vaccines against infections by such viruses, diagnostics for detecting such viruses and targets for therapeutics against such viruses. In particular, the invention relates to 3-D models identifying a proteinaceous substance comprising at least one virus epitope derived from the attachment protein of a virus from the family of paramyxoviridae, said epitope corresponding to an antigenic site present on the HN protein of paramyxovirus, which site is identified as one of loop beta 1L01, beta 1L23, beta 2L01, beta 2L23, beta 3L01, beta 3L23, beta 4L01, beta 4L23, beta 5L01, beta 5L23, beta 6L01 and beta 6L23, or a functional equivalent thereof. Also, the invention relates to a substance blocking the enzymatic activity of the morbillivirus H protein.