| 摘要 |
<p>Sulfonyl derivatives represented by general formula (I), salts of the same, and solvates of both; and application of them as drugs: [wherein R1 is hydrogen, hydroxyl, nitro or the like; R?2 and R3¿ are each independently hydrogen, halogeno or the like; R?4 and R5¿ are each independently hydrogen, halogeno or the like; Q1 is an optionally substituted saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group or the like; Q2 is a single bond, oxygen or the like; Q3 is, e.g., a group represented by formula (a); T1 is carbonyl or the like; and X?1 and X2¿ are each independently methylidyne or nitrogen]. These compounds exhibit potent Fxa inhibiting activities and serve as excellent anticoagulants which speedily exert satisfactory and persistent anti-thrombotic effects through oral administration and little cause adverse effects.</p> |
