ISOLATED PROTEINS HAVING RETINOL DEHYDROGENASE ACTIVITY, AND WHICH ASSOCIATE WITH RETINOL BINDING PROTEIN RECEPTORS

摘要

Isolated membrane associated proteins which have a molecular weight of from about 30 kD to about 36 kilodaltons as determined by SDS-PAGE, are disclosed. The proteins have 5cis retinol dehydrogenase activity, such as 9, 11 or 13 cis retinol dehydrogenase activity, or cis activity at more than one position. Other trans-retinol dehydrogenases are also disclosed. Nucleic acid molecules which code for the proteins are also disclosed.