发明名称 |
Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives |
摘要 |
The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4''-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A. |
申请公布号 |
US5892008(A) |
申请公布日期 |
1999.04.06 |
申请号 |
US19970991648 |
申请日期 |
1997.12.16 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
KU, YI-YIN;RILEY, DAVID A.;LEE, ELAINE C.;TIEN, JIEN-HEH |
分类号 |
C07H17/08;(IPC1-7):C07H1/00 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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