| 摘要 |
PCT No. PCT/EP94/00286 Sec. 371 Date Sep. 15, 1995 Sec. 102(e) Date Sep. 15, 1995 PCT Filed Feb. 2, 1994 PCT Pub. No. WO94/18325 PCT Pub. Date Aug. 18, 1994The invention relates to tumor necrosis factor muteins characterized in that the TNF- alpha amino acid sequence is mutated, or deleted totally or partially, in the region containing position 101 to 116 in such a way that: either the lectin-like activity is reduced with respect to TNF- alpha , or the toxic activity is reduced with respect to TNF- alpha ; and providing that said muteins have largely retained the tumoricidal activity of TNF- alpha ; and with said muteins possibly containing in their peptidic chain additional modifications consisting of substitutions and/or deletions and/or additions of one or several amino acid residues, and with said muteins being characterized in that they have retained the aforementioned activities; or a pharmaceutically acceptable salt thereof.
|
