Method for producing ester of (S)- gamma -halogenated- beta -hydroxybutyric acid

摘要

Microbial cells and/or a preparation thereof of a microorganism is allowed to act on ester of gamma -halogenated-acetoacetic acid, and its carbonyl group at beta -position is stereospecifically reduced to produce ester of (S)- gamma -halogenated- beta -hydroxybutyric acid in a short period of time at a highly accumulated degree and at a high yield, the microorganism being selected from the group consisting of those belonging to the genera Phoma, Nectria, Pseudonectria, Spondylocladium, Melanospora, Metarhizium, Gliocladium, Pestalotia, Pestalotiopsis, Curvularia, Hormonema, Sydowia, Sarcinomyces, Dothiora, Xanthothecium, Dothidea, Pringsheimia, and Selenophoma.