发明名称 |
T-cell vaccination for the treatment of multiple sclerosis |
摘要 |
Disclosed are methods and compositions useful for the treatment of autoimmune diseases. Methods for producing vaccines against autoreactive T-cells are disclosed. The vaccines so produced are capable of restoring a degree of immunologic self-tolerance sufficient to slow or halt the progression of autoimmune disorders. In a preferred embodiment of the invention, a vaccine is derived from attenuated autologous autoreactive T-cells that recognize a variety of myelin-derived proteins. Such vaccine compositions are useful for immunologic therapy for the treatment of multiple sclerosis (MS). |
申请公布号 |
AU9571398(A) |
申请公布日期 |
1999.04.05 |
申请号 |
AU19980095713 |
申请日期 |
1998.09.18 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
LESLIE P. WEINER;JORGE D. CORREALE |
分类号 |
A61K35/14;A61K39/00;A61P37/00;C12N5/08 |
主分类号 |
A61K35/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|