| 发明名称 |
METHOD FOR GENE TRANSFER USING BCL2 AND COMPOSITIONS USEFUL THEREIN |
| 摘要 |
A method for liver-directed gene therapy is described. The method involves transfer of Bcl2 and a selected transgene to hepatocytes. Bcl2 protects those hepatocytes which express it from apoptosis and permits proliferation of hepatocytes containing the transgene.
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| 申请公布号 |
CA2304131(A1) |
申请公布日期 |
1999.04.01 |
| 申请号 |
CA19982304131 |
申请日期 |
1998.09.18 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
WILSON, JAMES M.;CHEN, SHU-JEN |
| 分类号 |
A61K38/00;A61K48/00;C07K14/47;C07K14/505;C07K14/705;C07K14/81;C12N15/12;C12N15/65;C12N15/864;C12N15/87;(IPC1-7):C12N15/64;C12N15/18;C12N15/52;C12N15/86 |
主分类号 |
A61K38/00 |
| 代理机构 |
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