发明名称 |
3'-SUBSTITUTED NUCLEOSIDE DERIVATIVES |
摘要 |
<p>The invention relates to a 3'-substituted nucleoside derivative represented by the following general formula (1): <CHEM> wherein B means a nucleic acid base which may have a substituent, Z represents a lower alkynyl or lower alkenyl group which may be substituted by a group represented by the formula: <CHEM> in which R<a>, R<b> and R<c> are individually a lower alkyl group or a phenyl group, or an oxiranyl group which may have at least one lower alkyl group, R<1> and R<2> individually represent H or an ester-forming residue capable of easily leaving in a living body, and R<3> is H, a mono- or polyphosphoric acid residue, or an ester-forming residue capable of easily leaving in a living body, with the proviso that the sugar moiety is ribose, or a pharmaceutically acceptable salt thereof. The 3'-substituted nucleoside derivative according to the invention has an excellent antitumor activity and is hence useful for treatment for and prevention of cancers.</p> |
申请公布号 |
KR0177372(B1) |
申请公布日期 |
1999.04.01 |
申请号 |
KR19960074407 |
申请日期 |
1996.08.13 |
申请人 |
TAIHO PHARMACEUTICAL CO.,LTD;MATSUDA, AKIRA;SASAKI, TAKUMA |
发明人 |
MATSUDA, AKIRA;SASAKI, TAKUMA |
分类号 |
A61K31/7052;A61P35/00;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H19/20;(IPC1-7):C07H19/04;A61K31/70 |
主分类号 |
A61K31/7052 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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