发明名称 |
Racemisierungsfreies Verfahren zum Aufhängen von Aminosäuren auf einer Festphase |
摘要 |
<p>This invention pertains to amino acids attached to a solid support in a racemization free manner and to a method of covalently linking amino acids to solid supports for use in solid phase peptide syntheses, through a compound of the formula: <CHEM> wherein Z is an N alpha protecting group; B is one or more amino acids having protected or unprotected side chains; R1 and R2 are the same or different and are selected from the group consisting of hydrogen, a linear or branched, saturated or unsaturated alkyl, aryl and benzyl; A is a substituted or unsubstituted aromatic ring; Y is a hydrocarbon chain having a linear or branched, saturated or unsaturated alkyl, aryl or aralkyl which may be linked to A through an ether linkage; D is an oxygen or -NH- which may be linked to a spacer selected from the group consisting of one or more natural and unnatural amino acids or hydrocarbon chain having a linear or branched, saturated or unsaturated alkyl, aryl or aralkyl group, the spacer being linked to the carbonyl through an oxygen or -NH- linkage; and SS is a solid support which is bound to the carbonyl group through D.</p> |
申请公布号 |
DE68928932(D1) |
申请公布日期 |
1999.04.01 |
申请号 |
DE1989628932 |
申请日期 |
1989.12.22 |
申请人 |
PERSEPTIVE BIOSYSTEMS, INC., FRAMINGHAM, MASS., US |
发明人 |
BERNATOWICZ, MICHAEL S., CAMBRIDGE, MA 02139, US |
分类号 |
C07C69/708;C07C59/70;C07C229/02;C07C233/36;C07C233/47;C07C271/06;C07C311/29;C07C327/28;C07K1/04;C07K1/06;C07K1/113;C07K17/02;C07K17/06;(IPC1-7):C07K1/04 |
主分类号 |
C07C69/708 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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