发明名称 |
NON-PRIMATE LENTIVIRAL VECTORS AND PACKAGING SYSTEMS |
摘要 |
The invention provides non-primate lentiviral vectors, packaging cells and packaging plasmids based, for example, on feline and ungulate retroviruses. In particular, the packaging plasmids are designed for expression in human cells (which are also used as packaging cells). The vectors of the invention transduce human cells, including difficult to target non-dividing cells of the hematopoietic and nervous system, in vitro and in vivo. The vectors are suitable for general gene transfer to these cells and for gene therapy to treat conditions mediated by these non-dividing cells including cancer and HIV infection.
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申请公布号 |
WO9915641(A1) |
申请公布日期 |
1999.04.01 |
申请号 |
WO1998US19162 |
申请日期 |
1998.09.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
POESCHIA, ERIC, M.;LOONEY, DAVID, J.;WONG-STAAL, FLOSSIE |
分类号 |
A01K67/027;C12N5/10;C12N7/01;C12N15/09;C12N15/867;C12P21/00;(IPC1-7):C12N15/00;C12N5/00;A01N43/04 |
主分类号 |
A01K67/027 |
代理机构 |
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地址 |
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