PROCEDE FOR RECOVERY OF A beta -LACTAM ANTIBIOTIC

摘要

Process for recovery of a beta -lactam antibiotic from a mixture containing beta -lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between (3) and (8) at a concentration such that FG remains in solution, the solid beta -lactam antibiotic obtained being recovered and the remaining liquid being subjected to a concentrating step in which a slurry with solid beta -lactam antibiotic and solid FG develops, the slurry is brought to a pH at which the beta -lactam antibiotic dissolves, FG is separated as a solid and the beta -lactam antibiotic present in the mother liquor is at least partially utilized. Preferably, use is made of an initial mixture substantially contaiing beta -lactam antibiotic and FG originating from an enzymatic acylation reaction in which the corresponding beta -lactam nucleus, in particular 6-aminopenicillanic acid, 7-aminodesacetoxycephalosporanic acid and 7-amino-3-chloro-cef-3-em-4-carboxylic acid, is acylated with a D-phenyl glycine derivative.