Tumor vaccination by use of autologous or HLA-related antigen presenting cell (APC) transduced with a tumour antigen and a foreign antigen capable of causing an immune reaction

摘要

There is described a method for tumor vaccination with at least two subsequent administrations of a composition consisting of autologous or HLA-related cells which are capable of presenting an antigen in a patient, said cells being either tumor cells transduced with a gene not inherited in the patient (a foreign gene) or antigen presenting cells (APCs) transduced with a tumor antigen and a foreign antigen. This method leads to a destruction of the tumor by immune response.