Peptides specific for gluten-sensitive T-cells and use thereof

摘要

The invention relates to the field of immunology, more specifically to food-related immune enteropathies (gluten-sensitivities) such as celiac sprue, tropical sprue, giardiasis and food allergies of childhood, but also to disorders such as dermatitis herpetiformis (DH). The invention provides a method to find or characterise peptides that are recognised by intestinally derived gluten-specific T-cell which is instrumental in gluten sensitivity. The invention also provides such peptides which can be obtained from a prolamine, such as a gliadin, secalin, hordein, avenin and glutenins and provides peptides constituting a T-cell epitope obtainable from gliadin and glutenin, for example comprising the sequence SGQGSFQPSQQ or GQQGYYPTSPQQSGQ or derivatives thereof having similar properties.